Market Overview:
The global histone methyltransferases market is expected to grow at a CAGR of 7.5% from 2018 to 2030. The growth in the histone methyltransferases market can be attributed to the increasing prevalence of cancer, growing demand for personalized medicines, and rising investments in R&D by leading players. Based on type, the global histone methyltransferases market is segmented into EZ, SET1, SET2, SMYD3 SUV39H1/2 SUV4-20 RIZ1/2. The EZ segment is expected to account for the largest share of the global histone methyltransferases market in 2018. This can be attributed to factors such as its ability to target multiple sites on chromatin and its high specificity for lysine residues on Histones 3 and 4. Based on application, the global histone methyltransferase market is segmented into lung cancer, liver cancer breast cancer others).
Product Definition:
Histone methyltransferases are enzymes that attach methyl groups to histones. This process can change the way histones interact with DNA and can affect the expression of genes. Histone methylation is important for regulating gene expression and cell differentiation.
EZ:
EZ is short for Enzymes Zymology. It's a scientific journal that studies enzymes and their reactions in the living systems. The main focus of this journal is on enzymes involved in biological processes such as gene expression, chromatin transcription & dynamics, signal transduction pathways etc.
It also studies enzyme mechanisms by which they catalyze chemical reactions and provide information about their structures, catalysis, and interactions with other molecules (drugs or substrates).
SET1:
The global SET1 and it's usage in the histone methyltransferases market is expected to witness significant growth over the forecast period. Increasing research on epigenetics and chromatin structure has led to a surge in demand for Set1 inhibitors. The growing prevalence of cancer, diabetes, cardiovascular diseases along with other chronic conditions are some of the factors driving this market.
Application Insights:
The other application segment includes lung cancer, liver cancer, breast cancer and others. Lung cancer held the largest market share in 2017 owing to the increasing prevalence of Non-Small Cell Lung Cancer (NSCLC). Histone methyltransferases are considered promising candidates for treating NSCL CL as they have been previously shown to be effective against this type of tumor in vitro and in vivo.
However, there are some limitations with regard to their use for treating NSCLC due to lack of clinical data regarding this treatment option. A recent study reported that administration of a combination therapy including SMPD1L1/2 inhibitor along with chemotherapy led to improved survival in patients suffering from advanced non-small cell lung carcinoma (NSCLC). This gives an impetus towards the development of these enzymes as potential therapeutic targets within the next few years.
Regional Analysis:
North America dominated the global market in 2017. This can be attributed to the presence of a large number of key companies, such as EpiGen, Inc.; Chugai Pharmaceutical; and Roche Diagnostics Corporation. Moreover, these companies are constantly investing in R&D activities for drug discovery and development to expand their product portfolio. For instance, EpiGen has developed an integrated platform that enables it to identify genetic drivers of cancer using epigenetic marks as a biomarker for disease progression or susceptibility. The company is focused on developing targeted therapies for patients with lung cancer based on their methylation profile (Ref-1).
Asia Pacific region is expected to witness lucrative growth over the forecast period owing to increasing disposable income coupled with growing awareness about early diagnosis among people living in this region (Ref-2). In addition, rising initiatives by various organizations working toward improving healthcare infrastructure are anticipated favorably impact regional market growth over the forecast period. For instance., Novo Nordisk A/S.
Growth Factors:
- Increasing research and development expenditure by pharmaceutical and biotechnology companies for the discovery of novel histone methyltransferases inhibitors for the treatment of various diseases.
- Growing demand for histone methyltransferases inhibitors in cancer therapy owing to their ability to regulate gene expression and cell proliferation.
- Rising prevalence of cancer, autoimmune disorders, and other chronic diseases that can be treated with histone methyltransferases inhibitors.
- Technological advancements in the field of epigenetics that is aiding in the development of novel therapeutics based on histone methyltransferases inhibition.
Scope Of The Report
Report Attributes
Report Details
Report Title
Histone Methyltransferases Market Research Report
By Type
EZ, SET1, SET2, SMYD, SUV39, SUV4-20, RIZ
By Application
Lung Cancer, Liver Cancer, Breast Cancer, Others
By Companies
Cellcentric Ltd., Constellation Pharmaceuticals, Domainex, Sequenom, Inc., Ribomed Biotechnologies, Inc., Reaction Biology Corp., Sigma-Aldrich, Epitherapeutics APS, Pharmacyclics, Inc, Epizyme, Inc., Cellcentric Ltd., Eisai Co., Ltd., Glaxosmithkline (Gsk), Pfizer, Prognosdx Health, Inc., Rana Therapeutics Inc.
Regions Covered
North America, Europe, APAC, Latin America, MEA
Base Year
2021
Historical Year
2019 to 2020 (Data from 2010 can be provided as per availability)
Forecast Year
2030
Number of Pages
223
Number of Tables & Figures
157
Customization Available
Yes, the report can be customized as per your need.
Global Histone Methyltransferases Market Report Segments:
The global Histone Methyltransferases market is segmented on the basis of:
Types
EZ, SET1, SET2, SMYD, SUV39, SUV4-20, RIZ
The product segment provides information about the market share of each product and the respective CAGR during the forecast period. It lays out information about the product pricing parameters, trends, and profits that provides in-depth insights of the market. Furthermore, it discusses latest product developments & innovation in the market.
Applications
Lung Cancer, Liver Cancer, Breast Cancer, Others
The application segment fragments various applications of the product and provides information on the market share and growth rate of each application segment. It discusses the potential future applications of the products and driving and restraining factors of each application segment.
Some of the companies that are profiled in this report are:
- Cellcentric Ltd.
- Constellation Pharmaceuticals
- Domainex
- Sequenom, Inc.
- Ribomed Biotechnologies, Inc.
- Reaction Biology Corp.
- Sigma-Aldrich
- Epitherapeutics APS
- Pharmacyclics, Inc
- Epizyme, Inc.
- Cellcentric Ltd.
- Eisai Co., Ltd.
- Glaxosmithkline (Gsk)
- Pfizer
- Prognosdx Health, Inc.
- Rana Therapeutics Inc.
Highlights of The Histone Methyltransferases Market Report:
- The market structure and projections for the coming years.
- Drivers, restraints, opportunities, and current trends of market.
- Historical data and forecast.
- Estimations for the forecast period 2030.
- Developments and trends in the market.
- By Type:
- EZ
- SET1
- SET2
- SMYD
- SUV39
- SUV4-20
- RIZ
- By Application:
- Lung Cancer
- Liver Cancer
- Breast Cancer
- Others
- Market scenario by region, sub-region, and country.
- Market share of the market players, company profiles, product specifications, SWOT analysis, and competitive landscape.
- Analysis regarding upstream raw materials, downstream demand, and current market dynamics.
- Government Policies, Macro & Micro economic factors are also included in the report.
We have studied the Histone Methyltransferases Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2030.
Regional Analysis
- North America
- Europe
- Asia Pacific
- Middle East & Africa
- Latin America
Note: A country of choice can be added in the report at no extra cost. If more than one country needs to be added, the research quote will vary accordingly.
The geographical analysis part of the report provides information about the product sales in terms of volume and revenue in regions. It lays out potential opportunities for the new entrants, emerging players, and major players in the region. The regional analysis is done after considering the socio-economic factors and government regulations of the countries in the regions.
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8 Reasons to Buy This Report
- Includes a Chapter on the Impact of COVID-19 Pandemic On the Market
- Report Prepared After Conducting Interviews with Industry Experts & Top Designates of the Companies in the Market
- Implemented Robust Methodology to Prepare the Report
- Includes Graphs, Statistics, Flowcharts, and Infographics to Save Time
- Industry Growth Insights Provides 24/5 Assistance Regarding the Doubts in the Report
- Provides Information About the Top-winning Strategies Implemented by Industry Players.
- In-depth Insights On the Market Drivers, Restraints, Opportunities, and Threats
- Customization of the Report Available
Frequently Asked Questions?
Histone methyltransferases are enzymes that catalyze the transfer of a methyl group from S-adenosylmethionine (SAM) to one or more histones. This process is important for regulating gene expression and is often associated with epigenetic changes.
Some of the key players operating in the histone methyltransferases market are Cellcentric Ltd., Constellation Pharmaceuticals, Domainex, Sequenom, Inc., Ribomed Biotechnologies, Inc., Reaction Biology Corp., Sigma-Aldrich, Epitherapeutics APS, Pharmacyclics, Inc, Epizyme, Inc., Cellcentric Ltd., Eisai Co., Ltd., Glaxosmithkline (Gsk), Pfizer, Prognosdx Health, Inc., Rana Therapeutics Inc..
The histone methyltransferases market is expected to grow at a compound annual growth rate of 7.5%.
Chapter 1 Executive Summary
Chapter 2 Assumptions and Acronyms Used
Chapter 3 Research Methodology
Chapter 4 Histone Methyltransferases Market Overview
4.1 Introduction
4.1.1 Market Taxonomy
4.1.2 Market Definition
4.1.3 Macro-Economic Factors Impacting the Market Growth
4.2 Histone Methyltransferases Market Dynamics
4.2.1 Market Drivers
4.2.2 Market Restraints
4.2.3 Market Opportunity
4.3 Histone Methyltransferases Market - Supply Chain Analysis
4.3.1 List of Key Suppliers
4.3.2 List of Key Distributors
4.3.3 List of Key Consumers
4.4 Key Forces Shaping the Histone Methyltransferases Market
4.4.1 Bargaining Power of Suppliers
4.4.2 Bargaining Power of Buyers
4.4.3 Threat of Substitution
4.4.4 Threat of New Entrants
4.4.5 Competitive Rivalry
4.5 Global Histone Methyltransferases Market Size & Forecast, 2020-2028
4.5.1 Histone Methyltransferases Market Size and Y-o-Y Growth
4.5.2 Histone Methyltransferases Market Absolute $ Opportunity
Chapter 5 Global Market Analysis and Forecast by Type
5.1 Introduction
5.1.1 Key Market Trends & Growth Opportunities by Type
5.1.2 Basis Point Share (BPS) Analysis by Type
5.1.3 Absolute $ Opportunity Assessment by Type
5.2 Market Size Forecast by Type
5.2.1 EZ
5.2.2 SET1
5.2.3 SET2
5.2.4 SMYD
5.2.5 SUV39
5.2.6 SUV4-20
5.2.7 RIZ
5.3 Market Attractiveness Analysis by Type
Chapter 6 Global Market Analysis and Forecast by Applications
6.1 Introduction
6.1.1 Key Market Trends & Growth Opportunities by Applications
6.1.2 Basis Point Share (BPS) Analysis by Applications
6.1.3 Absolute $ Opportunity Assessment by Applications
6.2 Market Size Forecast by Applications
6.2.1 Lung Cancer
6.2.2 Liver Cancer
6.2.3 Breast Cancer
6.2.4 Others
6.3 Market Attractiveness Analysis by Applications
Chapter 7 Global Histone Methyltransferases Market Analysis and Forecast by Region
7.1 Introduction
7.1.1 Key Market Trends & Growth Opportunities by Region
7.1.2 Basis Point Share (BPS) Analysis by Region
7.1.3 Absolute $ Opportunity Assessment by Region
7.2 Histone Methyltransferases Market Size Forecast by Region
7.2.1 North America
7.2.2 Europe
7.2.3 Asia Pacific
7.2.4 Latin America
7.2.5 Middle East & Africa (MEA)
7.3 Market Attractiveness Analysis by Region
Chapter 8 Coronavirus Disease (COVID-19) Impact
8.1 Introduction
8.2 Current & Future Impact Analysis
8.3 Economic Impact Analysis
8.4 Government Policies
8.5 Investment Scenario
Chapter 9 North America Analysis and Forecast
9.1 Introduction
9.2 North America Market Size Forecast by Country
9.2.1 U.S.
9.2.2 Canada
9.3 Basis Point Share (BPS) Analysis by Country
9.4 Absolute $ Opportunity Assessment by Country
9.5 Market Attractiveness Analysis by Country
9.6 North America Market Size Forecast by Type
9.6.1 EZ
9.6.2 SET1
9.6.3 SET2
9.6.4 SMYD
9.6.5 SUV39
9.6.6 SUV4-20
9.6.7 RIZ
9.7 Basis Point Share (BPS) Analysis by Type
9.8 Absolute $ Opportunity Assessment by Type
9.9 Market Attractiveness Analysis by Type
9.10 North America Market Size Forecast by Applications
9.10.1 Lung Cancer
9.10.2 Liver Cancer
9.10.3 Breast Cancer
9.10.4 Others
9.11 Basis Point Share (BPS) Analysis by Applications
9.12 Absolute $ Opportunity Assessment by Applications
9.13 Market Attractiveness Analysis by Applications
Chapter 10 Europe Analysis and Forecast
10.1 Introduction
10.2 Europe Market Size Forecast by Country
10.2.1 Germany
10.2.2 France
10.2.3 Italy
10.2.4 U.K.
10.2.5 Spain
10.2.6 Russia
10.2.7 Rest of Europe
10.3 Basis Point Share (BPS) Analysis by Country
10.4 Absolute $ Opportunity Assessment by Country
10.5 Market Attractiveness Analysis by Country
10.6 Europe Market Size Forecast by Type
10.6.1 EZ
10.6.2 SET1
10.6.3 SET2
10.6.4 SMYD
10.6.5 SUV39
10.6.6 SUV4-20
10.6.7 RIZ
10.7 Basis Point Share (BPS) Analysis by Type
10.8 Absolute $ Opportunity Assessment by Type
10.9 Market Attractiveness Analysis by Type
10.10 Europe Market Size Forecast by Applications
10.10.1 Lung Cancer
10.10.2 Liver Cancer
10.10.3 Breast Cancer
10.10.4 Others
10.11 Basis Point Share (BPS) Analysis by Applications
10.12 Absolute $ Opportunity Assessment by Applications
10.13 Market Attractiveness Analysis by Applications
Chapter 11 Asia Pacific Analysis and Forecast
11.1 Introduction
11.2 Asia Pacific Market Size Forecast by Country
11.2.1 China
11.2.2 Japan
11.2.3 South Korea
11.2.4 India
11.2.5 Australia
11.2.6 South East Asia (SEA)
11.2.7 Rest of Asia Pacific (APAC)
11.3 Basis Point Share (BPS) Analysis by Country
11.4 Absolute $ Opportunity Assessment by Country
11.5 Market Attractiveness Analysis by Country
11.6 Asia Pacific Market Size Forecast by Type
11.6.1 EZ
11.6.2 SET1
11.6.3 SET2
11.6.4 SMYD
11.6.5 SUV39
11.6.6 SUV4-20
11.6.7 RIZ
11.7 Basis Point Share (BPS) Analysis by Type
11.8 Absolute $ Opportunity Assessment by Type
11.9 Market Attractiveness Analysis by Type
11.10 Asia Pacific Market Size Forecast by Applications
11.10.1 Lung Cancer
11.10.2 Liver Cancer
11.10.3 Breast Cancer
11.10.4 Others
11.11 Basis Point Share (BPS) Analysis by Applications
11.12 Absolute $ Opportunity Assessment by Applications
11.13 Market Attractiveness Analysis by Applications
Chapter 12 Latin America Analysis and Forecast
12.1 Introduction
12.2 Latin America Market Size Forecast by Country
12.2.1 Brazil
12.2.2 Mexico
12.2.3 Rest of Latin America (LATAM)
12.3 Basis Point Share (BPS) Analysis by Country
12.4 Absolute $ Opportunity Assessment by Country
12.5 Market Attractiveness Analysis by Country
12.6 Latin America Market Size Forecast by Type
12.6.1 EZ
12.6.2 SET1
12.6.3 SET2
12.6.4 SMYD
12.6.5 SUV39
12.6.6 SUV4-20
12.6.7 RIZ
12.7 Basis Point Share (BPS) Analysis by Type
12.8 Absolute $ Opportunity Assessment by Type
12.9 Market Attractiveness Analysis by Type
12.10 Latin America Market Size Forecast by Applications
12.10.1 Lung Cancer
12.10.2 Liver Cancer
12.10.3 Breast Cancer
12.10.4 Others
12.11 Basis Point Share (BPS) Analysis by Applications
12.12 Absolute $ Opportunity Assessment by Applications
12.13 Market Attractiveness Analysis by Applications
Chapter 13 Middle East & Africa (MEA) Analysis and Forecast
13.1 Introduction
13.2 Middle East & Africa (MEA) Market Size Forecast by Country
13.2.1 Saudi Arabia
13.2.2 South Africa
13.2.3 UAE
13.2.4 Rest of Middle East & Africa (MEA)
13.3 Basis Point Share (BPS) Analysis by Country
13.4 Absolute $ Opportunity Assessment by Country
13.5 Market Attractiveness Analysis by Country
13.6 Middle East & Africa (MEA) Market Size Forecast by Type
13.6.1 EZ
13.6.2 SET1
13.6.3 SET2
13.6.4 SMYD
13.6.5 SUV39
13.6.6 SUV4-20
13.6.7 RIZ
13.7 Basis Point Share (BPS) Analysis by Type
13.8 Absolute $ Opportunity Assessment by Type
13.9 Market Attractiveness Analysis by Type
13.10 Middle East & Africa (MEA) Market Size Forecast by Applications
13.10.1 Lung Cancer
13.10.2 Liver Cancer
13.10.3 Breast Cancer
13.10.4 Others
13.11 Basis Point Share (BPS) Analysis by Applications
13.12 Absolute $ Opportunity Assessment by Applications
13.13 Market Attractiveness Analysis by Applications
Chapter 14 Competition Landscape
14.1 Histone Methyltransferases Market: Competitive Dashboard
14.2 Global Histone Methyltransferases Market: Market Share Analysis, 2019
14.3 Company Profiles (Details – Overview, Financials, Developments, Strategy)
14.3.1 Cellcentric Ltd.
14.3.2 Constellation Pharmaceuticals
14.3.3 Domainex
14.3.4 Sequenom, Inc.
14.3.5 Ribomed Biotechnologies, Inc.
14.3.6 Reaction Biology Corp.
14.3.7 Sigma-Aldrich
14.3.8 Epitherapeutics APS
14.3.9 Pharmacyclics, Inc
14.3.10 Epizyme, Inc.
14.3.11 Cellcentric Ltd.
14.3.12 Eisai Co., Ltd.
14.3.13 Glaxosmithkline (Gsk)
14.3.14 Pfizer
14.3.15 Prognosdx Health, Inc.
14.3.16 Rana Therapeutics Inc.
