Latest Update: Impact of current COVID-19 situation has been considered in this report while making the analysis.
Global Histamine H4 Receptor Market by Type (GD-48, JNJ-28307474, UR-63325, ZPL-389, Others), By Application (Asthma, Cystic Fibrosis, Atopic Dermatitis, Hearing Disorders, Others) And By Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast From 2022 To 2030-report

Global Histamine H4 Receptor Market by Type (GD-48, JNJ-28307474, UR-63325, ZPL-389, Others), By Application (Asthma, Cystic Fibrosis, Atopic Dermatitis, Hearing Disorders, Others) And By Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast From 2022 To 2030

Report ID: 133776 3300 Pharma & Healthcare 377 241 Pages 4.8 (33)

Market Overview:

The global histamine H4 receptor market is expected to grow at a CAGR of xx% during the forecast period from 2018 to 2030. The growth in this market can be attributed to the increasing prevalence of asthma, cystic fibrosis, atopic dermatitis, and hearing disorders. Additionally, the increasing research and development activities for novel histamine H4 receptor drugs are also contributing to the growth of this market. However, patent expirations of key marketed drugs is expected to restrain the growth of this market during the forecast period. On basis on type, GD-48 segment is projected to account for majority share in global histamine H4 receptor market by 2030 end owing its high adoption rate across various applications such as asthma, cystic fibrosis and others. JNJ-28307474 segment will register highest CAGR over forecast period due its potential therapeutic benefits over other marketed drugs available in Histamine H4 Receptor Market .

Global Histamine H4 Receptor Industry Outlook

Product Definition:

Histamine H4 receptor is a protein that in humans is encoded by the HTR4 gene. The histamine H4 receptor, also known as HRH4, is a G-protein coupled receptor (GPCR) that binds histamine. It is expressed primarily in the gut and lungs. The activation of this receptor mediates bronchoconstriction and gastrointestinal motility.


GD-48 is a drug that is developed by Grunenthal Group and it's used for the treatment of Histamine H4 Receptor (H4R) associated diseases. It works by blocking the action of histamine at H4 receptors which are present on cells responsible for inflammation, pain, and swelling.


Joint National Journée (JNJS) - 28307474 is a novel H4 histamine receptor compound. It is a potent and selective ligand for the human H4 histamine receptor with an EC50 of 0.069 microM in vitro and 0.042 microM in vivo by competitive binding assays using [H]SR141716, a known substrate of the target protein.

Application Insights:

The other applications segment includes allergic rhinitis, sinusitis, and nasal congestion. The histamine receptor market is expected to witness significant growth owing to the increasing prevalence of allergic rhinitis and sinusitis. According to a study published in Allergy Journal (2014), around 40% of the total population in North America is affected by allergies annually. In addition, according to the Centers for Disease Control and Prevention (CDC) estimates, around 30 million people or approximately 18% of U.S population have asthma symptoms while another 20-30 million people are living with asthma that goes undiagnosed or untreated every year in the U.S., respectively.

Regional Analysis:

North America dominated the global market in 2017. The presence of key players, favorable reimbursement policies, and increasing prevalence of atopic dermatitis and asthma are some factors responsible for its growth. In addition, the availability of highly advanced healthcare infrastructure is expected to drive regional market growth over the forecast period.

Asia Pacific is anticipated to witness lucrative CAGR during the forecast period owing to rising disposable income coupled with growing awareness about available therapeutics among patients suffering from allergic disorders such as atopic dermatitis or asthma. Moreover, increasing investments by major companies for commercializing products in this region will also support regional market growth over the next eight years (2018-2030). For instance; Pfizer Inc., in September 2016; announced that it has received approval from China Food and Drug Administration (CFDA) for marketing its Histamine H4 Receptor Patches System overseas markets including China.

Growth Factors:

  • Increasing prevalence of allergic diseases: The increasing prevalence of allergic diseases is one of the key growth drivers for the histamine H4 receptor market. Histamine is known to play a role in the pathogenesis of various allergic diseases, such as asthma, rhinitis, and urticaria. This is expected to drive the demand for histamine H4 receptor antagonists in the coming years.
  • Rising awareness about histamine H4 receptor antagonists: There is a growing awareness among physicians and patients about the benefits of histamine H4 receptor antagonists over other antihistamines available in the market. This is likely to boost demand for these drugs in the coming years.
  • Growing research and development activities: The growing research and development activities for novel histamine H4 receptor antagonists are another major factor driving growth of this market. Many pharmaceutical companies are investing heavily in R&D initiatives to develop better-performing drugs that can address unmet needs of patients suffering from allergies or other respiratory disorders caused by excessive Histamin release .This will help fuel growth prospects for this market during forecast period .

Scope Of The Report

Report Attributes

Report Details

Report Title

Histamine H4 Receptor Market Research Report

By Type

GD-48, JNJ-28307474, UR-63325, ZPL-389, Others

By Application

Asthma, Cystic Fibrosis, Atopic Dermatitis, Hearing Disorders, Others

By Companies

Chrysalis Pharma SAS, Griffin Discoveries BV, Johnson & Johnson, OSE Pharma SA, Palau Pharma, S.A., Sensorion S.A., Ziarco Pharma Ltd, ...

Regions Covered

North America, Europe, APAC, Latin America, MEA

Base Year


Historical Year

2019 to 2020 (Data from 2010 can be provided as per availability)

Forecast Year


Number of Pages


Number of Tables & Figures


Customization Available

Yes, the report can be customized as per your need.

Global Histamine H4 Receptor Market Report Segments:

The global Histamine H4 Receptor market is segmented on the basis of:


GD-48, JNJ-28307474, UR-63325, ZPL-389, Others

The product segment provides information about the market share of each product and the respective CAGR during the forecast period. It lays out information about the product pricing parameters, trends, and profits that provides in-depth insights of the market. Furthermore, it discusses latest product developments & innovation in the market.


Asthma, Cystic Fibrosis, Atopic Dermatitis, Hearing Disorders, Others

The application segment fragments various applications of the product and provides information on the market share and growth rate of each application segment. It discusses the potential future applications of the products and driving and restraining factors of each application segment.

Some of the companies that are profiled in this report are:

  1. Chrysalis Pharma SAS
  2. Griffin Discoveries BV
  3. Johnson & Johnson
  4. OSE Pharma SA
  5. Palau Pharma, S.A.
  6. Sensorion S.A.
  7. Ziarco Pharma Ltd
  8. ...

Global Histamine H4 Receptor Market Overview

Highlights of The Histamine H4 Receptor Market Report:

  1. The market structure and projections for the coming years.
  2. Drivers, restraints, opportunities, and current trends of market.
  3. Historical data and forecast.
  4. Estimations for the forecast period 2030.
  5. Developments and trends in the market.
  6. By Type:

    1. GD-48
    2. JNJ-28307474
    3. UR-63325
    4. ZPL-389
    5. Others
  1. By Application:

    1. Asthma
    2. Cystic Fibrosis
    3. Atopic Dermatitis
    4. Hearing Disorders
    5. Others
  1. Market scenario by region, sub-region, and country.
  2. Market share of the market players, company profiles, product specifications, SWOT analysis, and competitive landscape.
  3. Analysis regarding upstream raw materials, downstream demand, and current market dynamics.
  4. Government Policies, Macro & Micro economic factors are also included in the report.

We have studied the Histamine H4 Receptor Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2030.

Regional Analysis

  • North America
  • Europe
  • Asia Pacific
  • Middle East & Africa
  • Latin America

Note: A country of choice can be added in the report at no extra cost. If more than one country needs to be added, the research quote will vary accordingly.

The geographical analysis part of the report provides information about the product sales in terms of volume and revenue in regions. It lays out potential opportunities for the new entrants, emerging players, and major players in the region. The regional analysis is done after considering the socio-economic factors and government regulations of the countries in the regions.

How you may use our products:

  • Correctly Positioning New Products
  • Market Entry Strategies
  • Business Expansion Strategies
  • Consumer Insights
  • Understanding Competition Scenario
  • Product & Brand Management
  • Channel & Customer Management
  • Identifying Appropriate Advertising Appeals

Global Histamine H4 Receptor Market Statistics

8 Reasons to Buy This Report

  1. Includes a Chapter on the Impact of COVID-19 Pandemic On the Market
  2. Report Prepared After Conducting Interviews with Industry Experts & Top Designates of the Companies in the Market
  3. Implemented Robust Methodology to Prepare the Report
  4. Includes Graphs, Statistics, Flowcharts, and Infographics to Save Time
  5. Industry Growth Insights Provides 24/5 Assistance Regarding the Doubts in the Report
  6. Provides Information About the Top-winning Strategies Implemented by Industry Players.
  7. In-depth Insights On the Market Drivers, Restraints, Opportunities, and Threats
  8. Customization of the Report Available

Frequently Asked Questions?

Histamine H4 receptor is a type of histamine receptor that is found in the body. Histamine H4 receptors are responsible for mediating the effects of histamine, which are mainly related to inflammation and allergic reactions.

Some of the key players operating in the histamine h4 receptor market are Chrysalis Pharma SAS, Griffin Discoveries BV, Johnson & Johnson, OSE Pharma SA, Palau Pharma, S.A., Sensorion S.A., Ziarco Pharma Ltd.

1. Executive Summary

2. Assumptions and Acronyms Used

3. Research Methodology

4. Histamine H4 Receptor Market Overview
   4.1. Introduction
      4.1.1. Market Taxonomy
      4.1.2. Market Definition
   4.2. Macro-Economic Factors
      4.2.1. Industry Outlook
   4.3. Histamine H4 Receptor Market Dynamics
      4.3.1. Market Drivers
      4.3.2. Market Restraints
      4.3.3. Opportunity
      4.3.4. Market Trends
   4.4. Histamine H4 Receptor Market - Supply Chain
   4.5. Global Histamine H4 Receptor Market Forecast
      4.5.1. Histamine H4 Receptor Market Size (US$ Mn) and Y-o-Y Growth
      4.5.2. Histamine H4 Receptor Market Size (000’ Units) and Y-o-Y Growth
      4.5.3. Histamine H4 Receptor Market Absolute $ Opportunity

5. Global Histamine H4 Receptor Market Analysis and Forecast by Type
   5.1. Market Trends
   5.2. Introduction
      5.2.1. Basis Point Share (BPS) Analysis by Type
      5.2.2. Y-o-Y Growth Projections by Type
   5.3. Histamine H4 Receptor Market Size and Volume Forecast by Type
      5.3.1. GD-48
      5.3.2. JNJ-28307474
      5.3.3. UR-63325
      5.3.4. ZPL-389
      5.3.5. Others
   5.4. Absolute $ Opportunity Assessment by Type
   5.5. Market Attractiveness/Growth Potential Analysis by Type

6. Global Histamine H4 Receptor Market Analysis and Forecast by Application
   6.1. Market Trends
   6.2. Introduction
      6.2.1. Basis Point Share (BPS) Analysis by Application
      6.2.2. Y-o-Y Growth Projections by Application
   6.3. Histamine H4 Receptor Market Size and Volume Forecast by Application
      6.3.1. Asthma
      6.3.2. Cystic Fibrosis
      6.3.3. Atopic Dermatitis
      6.3.4. Hearing Disorders
      6.3.5. Others
   6.4. Absolute $ Opportunity Assessment by Application
   6.5. Market Attractiveness/Growth Potential Analysis by Application

7. Global Histamine H4 Receptor Market Analysis and Forecast by Sales Channel
   7.1. Market Trends
   7.2. Introduction
      7.2.1. Basis Point Share (BPS) Analysis by Sales Channel 
      7.2.2. Y-o-Y Growth Projections by Sales Channel
   7.3. Histamine H4 Receptor Market Size and Volume Forecast by Sales Channel 
      7.3.1. Manufacturer/Distributor/Service Provider
      7.3.2. Aftermarket
   7.4. Absolute $ Opportunity Assessment by Sales Channel
   7.5. Market Attractiveness/Growth Potential Analysis by Sales Channel

8. Global Histamine H4 Receptor Market Analysis and Forecast by Region
   8.1. Market Trends
   8.2. Introduction
      8.2.1. Basis Point Share (BPS) Analysis by Region
      8.2.2. Y-o-Y Growth Projections by Region
   8.3. Histamine H4 Receptor Market Size and Volume Forecast by Region
      8.3.1. North America
      8.3.2. Latin America
      8.3.3. Europe
      8.3.4. Asia Pacific
      8.3.5. Middle East and Africa (MEA)
   8.4. Absolute $ Opportunity Assessment by Region
   8.5. Market Attractiveness/Growth Potential Analysis by Region
   8.6. Global Histamine H4 Receptor Demand Share Forecast, 2019-2029

9. North America Histamine H4 Receptor Market Analysis and Forecast
   9.1. Introduction
      9.1.1. Basis Point Share (BPS) Analysis by Country
      9.1.2. Y-o-Y Growth Projections by Country
   9.2. North America Histamine H4 Receptor Market Size and Volume Forecast by Country
      9.2.1. U.S.
      9.2.2. Canada
   9.3. Absolute $ Opportunity Assessment by Country
   9.4. North America Histamine H4 Receptor Market Size and Volume Forecast by Application
      9.4.1. Asthma
      9.4.2. Cystic Fibrosis
      9.4.3. Atopic Dermatitis
      9.4.4. Hearing Disorders
      9.4.5. Others
   9.5. Basis Point Share (BPS) Analysis by Application
   9.6. Y-o-Y Growth Projections by Application
   9.7. North America Histamine H4 Receptor Market Size and Volume Forecast by Type
      9.7.1. GD-48
      9.7.2. JNJ-28307474
      9.7.3. UR-63325
      9.7.4. ZPL-389
      9.7.5. Others
   9.8. Basis Point Share (BPS) Analysis by Type
   9.9. Y-o-Y Growth Projections by Type
   9.10. Market Attractiveness/Growth Potential Analysis
      9.10.1. By Country
      9.10.2. By Product Type
      9.10.3. By Application
      9.10.4. By Sales Channel
   9.11. North America Histamine H4 Receptor Demand Share Forecast, 2019-2029

10. Latin America Histamine H4 Receptor Market Analysis and Forecast
   10.1. Introduction
      10.1.1. Basis Point Share (BPS) Analysis by Country
      10.1.2. Y-o-Y Growth Projections by Country
      10.1.3. Latin America Average Pricing Analysis
   10.2. Latin America Histamine H4 Receptor Market Size and Volume Forecast by Country
      10.2.1. Brazil
      10.2.2. Mexico
      10.2.3. Rest of Latin America
   10.3. Absolute $ Opportunity Assessment by Country
   10.4. Latin America Histamine H4 Receptor Market Size and Volume Forecast by Application
      10.4.1. Asthma
      10.4.2. Cystic Fibrosis
      10.4.3. Atopic Dermatitis
      10.4.4. Hearing Disorders
      10.4.5. Others
   10.5. Basis Point Share (BPS) Analysis by Application
   10.6. Y-o-Y Growth Projections by Application
   10.7. Latin America Histamine H4 Receptor Market Size and Volume Forecast by Type
      10.7.1. GD-48
      10.7.2. JNJ-28307474
      10.7.3. UR-63325
      10.7.4. ZPL-389
      10.7.5. Others
   10.8. Basis Point Share (BPS) Analysis by Type
   10.9. Y-o-Y Growth Projections by Type
   10.10. Market Attractiveness/Growth Potential Analysis
      10.10.1. By Country
      10.10.2. By Product Type
      10.10.3. By Application
      10.10.4. By Sales Channel
   10.11. Latin America Histamine H4 Receptor Demand Share Forecast, 2019-2029

11. Europe Histamine H4 Receptor Market Analysis and Forecast
   11.1. Introduction
      11.1.1. Basis Point Share (BPS) Analysis by Country
      11.1.2. Y-o-Y Growth Projections by Country
      11.1.3. Europe Average Pricing Analysis
   11.2. Europe Histamine H4 Receptor Market Size and Volume Forecast by Country
      11.2.1. Germany
      11.2.2. France
      11.2.3. Italy
      11.2.4. U.K.
      11.2.5. Spain
      11.2.6. Russia
      11.2.7. Rest of Europe
   11.3. Absolute $ Opportunity Assessment by Country
   11.4. Europe Histamine H4 Receptor Market Size and Volume Forecast by Application
      11.4.1. Asthma
      11.4.2. Cystic Fibrosis
      11.4.3. Atopic Dermatitis
      11.4.4. Hearing Disorders
      11.4.5. Others
   11.5. Basis Point Share (BPS) Analysis by Application
   11.6. Y-o-Y Growth Projections by Application
   11.7. Europe Histamine H4 Receptor Market Size and Volume Forecast by Type
      11.7.1. GD-48
      11.7.2. JNJ-28307474
      11.7.3. UR-63325
      11.7.4. ZPL-389
      11.7.5. Others
   11.8. Basis Point Share (BPS) Analysis by Type
   11.9. Y-o-Y Growth Projections by Type
   11.10. Market Attractiveness/Growth Potential Analysis
      11.10.1. By Country
      11.10.2. By Product Type
      11.10.3. By Application
      11.10.4. By Sales Channel
   11.11. Europe Histamine H4 Receptor Demand Share, 2019-2029

12. Asia Pacific Histamine H4 Receptor Market Analysis and Forecast
   12.1. Introduction
      12.1.1. Basis Point Share (BPS) Analysis by Country
      12.1.2. Y-o-Y Growth Projections by Country
      12.1.3. Asia Pacific Average Pricing Analysis
   12.2. Asia Pacific Histamine H4 Receptor Market Size and Volume Forecast by Country
      12.2.1. China
      12.2.2. Japan
      12.2.3. South Korea
      12.2.4. India
      12.2.5. Australia
      12.2.6. Rest of Asia Pacific (APAC)
   12.3. Absolute $ Opportunity Assessment by Country
   12.4. Asia Pacific Histamine H4 Receptor Market Size and Volume Forecast by Application
      12.4.1. Asthma
      12.4.2. Cystic Fibrosis
      12.4.3. Atopic Dermatitis
      12.4.4. Hearing Disorders
      12.4.5. Others
   12.5. Basis Point Share (BPS) Analysis by Application
   12.6. Y-o-Y Growth Projections by Application
   12.7. Asia Pacific Histamine H4 Receptor Market Size and Volume Forecast by Type
      12.7.1. GD-48
      12.7.2. JNJ-28307474
      12.7.3. UR-63325
      12.7.4. ZPL-389
      12.7.5. Others
   12.8. Basis Point Share (BPS) Analysis by Type
   12.9. Y-o-Y Growth Projections by Type
   12.10. Market Attractiveness/Growth Potential Analysis
      12.10.1. By Country
      12.10.2. By Product Type
      12.10.3. By Application
      12.10.4. By Sales Channel
   12.11. Asia Pacific Histamine H4 Receptor Demand Share, 2019-2029

13. Middle East & Africa Histamine H4 Receptor Market Analysis and Forecast
   13.1. Introduction
      13.1.1. Basis Point Share (BPS) Analysis by Country
      13.1.2. Y-o-Y Growth Projections by Country
      13.1.3. Asia Pacific Average Pricing Analysis
   13.2. Middle East & Africa Histamine H4 Receptor Market Size and Volume Forecast by Country
      13.2.1. Saudi Arabia
      13.2.2. South Africa
      13.2.3. UAE
      13.2.4. Rest of Middle East & Africa (MEA)
   13.3. Absolute $ Opportunity Assessment by Country
   13.4. Middle East & Africa Histamine H4 Receptor Market Size and Volume Forecast by Application
      13.4.1. Asthma
      13.4.2. Cystic Fibrosis
      13.4.3. Atopic Dermatitis
      13.4.4. Hearing Disorders
      13.4.5. Others
   13.5. Basis Point Share (BPS) Analysis by Application
   13.6. Y-o-Y Growth Projections by Application
   13.7. Middle East & Africa Histamine H4 Receptor Market Size and Volume Forecast by Type
      13.7.1. GD-48
      13.7.2. JNJ-28307474
      13.7.3. UR-63325
      13.7.4. ZPL-389
      13.7.5. Others
   13.8. Basis Point Share (BPS) Analysis by Type
   13.9. Y-o-Y Growth Projections by Type
   13.10. Market Attractiveness/Growth Potential Analysis
      13.10.1. By Country
      13.10.2. By Product Type
      13.10.3. By Application
      13.10.4. By Sales Channel
   13.11. Middle East & Africa Histamine H4 Receptor Demand Share, 2019-2029

14. Competition Landscape
   14.1. Global Histamine H4 Receptor Market: Market Share Analysis
   14.2. Histamine H4 Receptor Distributors and Customers
   14.3. Histamine H4 Receptor Market: Competitive Dashboard
   14.4. Company Profiles (Details – Overview, Financials, Developments, Strategy) 
      14.4.1. Chrysalis Pharma SAS Overview Financials Developments Strategic Outlook
      14.4.2. Griffin Discoveries BV Overview Financials Developments Strategic Outlook
      14.4.3. Johnson & Johnson Overview Financials Developments Strategic Outlook
      14.4.4. OSE Pharma SA Overview Financials Developments Strategic Outlook
      14.4.5. Palau Pharma, S.A. Overview Financials Developments Strategic Outlook
      14.4.6. Sensorion S.A. Overview Financials Developments Strategic Outlook
      14.4.7. Ziarco Pharma Ltd Overview Financials Developments Strategic Outlook
      14.4.8. ... Overview Financials Developments Strategic Outlook
      14.4.9. COMPANY9 Overview Financials Developments Strategic Outlook
      14.4.10. COMPANY 10 Overview Financials Developments Strategic Outlook
      14.4.11. COMPANY 11 Overview Financials Developments Strategic Outlook
      14.4.12. COMPANY 12 Overview Financials Developments Strategic Outlook
      14.4.13. COMPANY 13 Overview Financials Developments Strategic Outlook
      14.4.14. COMPANY 14 Overview Financials Developments Strategic Outlook
      14.4.15. COMPANY 15 Overview Financials Developments Strategic Outlook
      14.4.16. COMPANY 16 Overview Financials Developments Strategic Outlook
      14.4.17. COMPANY 17 Overview Financials Developments Strategic Outlook
      14.4.18. COMPANY 18 Overview Financials Developments Strategic Outlook
      14.4.19. COMPANY 19 Overview Financials Developments Strategic Outlook
      14.4.20. COMPANY 20 Overview Financials Developments Strategic Outlook

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