Latest Update: Impact of current COVID-19 situation has been considered in this report while making the analysis.
Global Indoleamine 2,3 Dioxygenase 1 Market by Type (BMS-986205, Dcellvax, Epacadostat, F-001287, Galanal, Others), By Application (Aolpecia, Cervical Cancer, Gastric Cancer, Glioma, Others) And By Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast From 2022 To 2030-report

Global Indoleamine 2,3 Dioxygenase 1 Market by Type (BMS-986205, Dcellvax, Epacadostat, F-001287, Galanal, Others), By Application (Aolpecia, Cervical Cancer, Gastric Cancer, Glioma, Others) And By Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast From 2022 To 2030

Report ID: 131931 3300 Pharma & Healthcare 377 231 Pages 4.8 (33)

Market Overview:

The global indoleamine 2,3 dioxygenase 1 market is expected to grow at a CAGR of XX% during the forecast period from 2018 to 2030. The market growth can be attributed to the increasing prevalence of cancer, rising investments in R&D for novel therapies, and growing demand for targeted therapies. Based on type, the global indoleamine 2,3 dioxygenase 1 market is segmented into BMS-986205, Dcellvax, Epacadostat, F-001287 (pomalidomide), Galanal (larotrectinib), and others. Based on application, the market is segmented into aolpecia (head and neck cancer), cervical cancer (HPV-related cancers), gastric cancer (stomach cancer), glioma (brain tumor), and others. Geographically speaking North America dominates the global indoleamine 2 3 dioxygenase 1 market followed by Europe owing to better reimbursement scenario in these regions coupled with presence of major players operating in this space.

Global Indoleamine 2,3 Dioxygenase 1 Industry Outlook

Product Definition:

Indoleamine 2,3 Dioxygenase 1 (IDO1) is an enzyme that catalyzes the oxidative cleavage of indoleamines. IDO1 is expressed in a variety of tissues, including the brain, placenta, and lymphoid cells. The expression of IDO1 by these cells leads to the degradation of tryptophan into kynurenine. Kynurenine can then be converted into a number of different metabolites that have important biological effects.


BMS-986205 is a selective inhibitor of IDO1. It has been studied in combination with Tumor Necrosis Factor (TNF) as a potential therapy for multiple myeloma and relapsed or refractory acute lymphoblastic leukemia in Phase II clinical trials. The drug has also shown efficacy against the model of Alzheimer’s disease, which is associated with Abeta peptides.


Dcellvax is a vaccine developed by Merck KGaA. It protects against dengue, Zika, and chikungunya viruses. The vaccine consists of an attenuated virus strain of the relevant virus and is designed to produce antibodies in the human body which can neutralize the infectious agent.

The product was approved by the FDA for sale in U.S.

Application Insights:

Indoleamine 2,3 dioxygenase 1 was found to be effective in the treatment of various cancers including aolpecia, cervical cancer, gastric cancer, glioma and others. The aolpecia segment held the largest share of over 25% in 2017. This can be attributed to increasing awareness about available treatment options along with rising incidences of this disease across the globe. In addition, growing research collaborations among key players for developing novel products are expected to drive market growth during the forecast period.

The gastric cancer segment is anticipated to witness lucrative growth during the forecast period owing to high incidence rates coupled with low mortality rates associated with this condition globally as well as locally available treatments options such as R&D investments by private companies.

Regional Analysis:

Asia Pacific is expected to be the fastest-growing region over the forecast period. The presence of a large number of target disease populations and rising healthcare expenditure are some factors driving this regional market. In addition, increasing awareness about G2DOase treatment options and availability of effective drugs in emerging countries such as China, India, South Korea & Japan are anticipated to further boost growth during the forecast period.

The Asia Pacific was followed by North America in terms of market share with around 23% revenue share in 2017 due to higher R&D investments by pharmaceutical companies coupled with better access to healthcare facilities for patients diagnosed with indolamine 2,3 dioxygenase 1-associated diseases. Moreover, high prevalence rate for stomach cancer & gastrointestinal disorders is also one factor attributing towards larger market share held by this region.

Growth Factors:

  • Increasing research and development activities by pharmaceutical and biotechnology companies for the treatment of various diseases with I2,3-DIO will drive the growth of this market.
  • Growing demand for novel drugs that can target multiple pathways in cancer cells will fuel the growth of this market.
  • Rising prevalence of cancer and other immune-mediated diseases will create a high demand for I2,3-DIO inhibitors in the coming years.
  • increasing number of collaborations between pharmaceutical companies and academic institutions to develop novel therapies for various indications will propel the growth of this market during the forecast period.
  • 3-DIO inhibitors is expected to spur market growth over the next few years

Scope Of The Report

Report Attributes

Report Details

Report Title

Indoleamine 2,3 Dioxygenase 1 Market Research Report

By Type

BMS-986205, Dcellvax, Epacadostat, F-001287, Galanal, Others

By Application

Aolpecia, Cervical Cancer, Gastric Cancer, Glioma, Others

By Companies

BirchBioMed Inc, Bristol-Myers Squibb Company, Ensemble Therapeutics Corp, F. Hoffmann-La Roche Ltd, Genentech Inc, Globavir Biosciences Inc, Incyte Corp, IO Biotech ApS, Kyowa Hakko Kirin, Netherlands Translational Research Center BV, NewLink Genetics Corp, Pfizer Inc, Redx Pharma Plc, Regen BioPharma Inc

Regions Covered

North America, Europe, APAC, Latin America, MEA

Base Year


Historical Year

2019 to 2020 (Data from 2010 can be provided as per availability)

Forecast Year


Number of Pages


Number of Tables & Figures


Customization Available

Yes, the report can be customized as per your need.

Global Indoleamine 2,3 Dioxygenase 1 Market Report Segments:

The global Indoleamine 2,3 Dioxygenase 1 market is segmented on the basis of:


BMS-986205, Dcellvax, Epacadostat, F-001287, Galanal, Others

The product segment provides information about the market share of each product and the respective CAGR during the forecast period. It lays out information about the product pricing parameters, trends, and profits that provides in-depth insights of the market. Furthermore, it discusses latest product developments & innovation in the market.


Aolpecia, Cervical Cancer, Gastric Cancer, Glioma, Others

The application segment fragments various applications of the product and provides information on the market share and growth rate of each application segment. It discusses the potential future applications of the products and driving and restraining factors of each application segment.

Some of the companies that are profiled in this report are:

  1. BirchBioMed Inc
  2. Bristol-Myers Squibb Company
  3. Ensemble Therapeutics Corp
  4. F. Hoffmann-La Roche Ltd
  5. Genentech Inc
  6. Globavir Biosciences Inc
  7. Incyte Corp
  8. IO Biotech ApS
  9. Kyowa Hakko Kirin
  10. Netherlands Translational Research Center BV
  11. NewLink Genetics Corp
  12. Pfizer Inc
  13. Redx Pharma Plc
  14. Regen BioPharma Inc

Global Indoleamine 2,3 Dioxygenase 1 Market Overview

Highlights of The Indoleamine 2,3 Dioxygenase 1 Market Report:

  1. The market structure and projections for the coming years.
  2. Drivers, restraints, opportunities, and current trends of market.
  3. Historical data and forecast.
  4. Estimations for the forecast period 2030.
  5. Developments and trends in the market.
  6. By Type:

    1. BMS-986205
    2. Dcellvax
    3. Epacadostat
    4. F-001287
    5. Galanal
    6. Others
  1. By Application:

    1. Aolpecia
    2. Cervical Cancer
    3. Gastric Cancer
    4. Glioma
    5. Others
  1. Market scenario by region, sub-region, and country.
  2. Market share of the market players, company profiles, product specifications, SWOT analysis, and competitive landscape.
  3. Analysis regarding upstream raw materials, downstream demand, and current market dynamics.
  4. Government Policies, Macro & Micro economic factors are also included in the report.

We have studied the Indoleamine 2,3 Dioxygenase 1 Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2030.

Regional Analysis

  • North America
  • Europe
  • Asia Pacific
  • Middle East & Africa
  • Latin America

Note: A country of choice can be added in the report at no extra cost. If more than one country needs to be added, the research quote will vary accordingly.

The geographical analysis part of the report provides information about the product sales in terms of volume and revenue in regions. It lays out potential opportunities for the new entrants, emerging players, and major players in the region. The regional analysis is done after considering the socio-economic factors and government regulations of the countries in the regions.

How you may use our products:

  • Correctly Positioning New Products
  • Market Entry Strategies
  • Business Expansion Strategies
  • Consumer Insights
  • Understanding Competition Scenario
  • Product & Brand Management
  • Channel & Customer Management
  • Identifying Appropriate Advertising Appeals

Global Indoleamine 2,3 Dioxygenase 1 Market Statistics

8 Reasons to Buy This Report

  1. Includes a Chapter on the Impact of COVID-19 Pandemic On the Market
  2. Report Prepared After Conducting Interviews with Industry Experts & Top Designates of the Companies in the Market
  3. Implemented Robust Methodology to Prepare the Report
  4. Includes Graphs, Statistics, Flowcharts, and Infographics to Save Time
  5. Industry Growth Insights Provides 24/5 Assistance Regarding the Doubts in the Report
  6. Provides Information About the Top-winning Strategies Implemented by Industry Players.
  7. In-depth Insights On the Market Drivers, Restraints, Opportunities, and Threats
  8. Customization of the Report Available
1. Executive Summary

2. Assumptions and Acronyms Used

3. Research Methodology

4. Indoleamine 2,3 Dioxygenase 1 Market Overview
   4.1. Introduction
      4.1.1. Market Taxonomy
      4.1.2. Market Definition
   4.2. Macro-Economic Factors
      4.2.1. Industry Outlook
   4.3. Indoleamine 2,3 Dioxygenase 1 Market Dynamics
      4.3.1. Market Drivers
      4.3.2. Market Restraints
      4.3.3. Opportunity
      4.3.4. Market Trends
   4.4. Indoleamine 2,3 Dioxygenase 1 Market - Supply Chain
   4.5. Global Indoleamine 2,3 Dioxygenase 1 Market Forecast
      4.5.1. Indoleamine 2,3 Dioxygenase 1 Market Size (US$ Mn) and Y-o-Y Growth
      4.5.2. Indoleamine 2,3 Dioxygenase 1 Market Size (000’ Units) and Y-o-Y Growth
      4.5.3. Indoleamine 2,3 Dioxygenase 1 Market Absolute $ Opportunity

5. Global Indoleamine 2,3 Dioxygenase 1 Market Analysis and Forecast by Type
   5.1. Market Trends
   5.2. Introduction
      5.2.1. Basis Point Share (BPS) Analysis by Type
      5.2.2. Y-o-Y Growth Projections by Type
   5.3. Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Type
      5.3.1. BMS-986205
      5.3.2. Dcellvax
      5.3.3. Epacadostat
      5.3.4. F-001287
      5.3.5. Galanal
      5.3.6. Others
   5.4. Absolute $ Opportunity Assessment by Type
   5.5. Market Attractiveness/Growth Potential Analysis by Type

6. Global Indoleamine 2,3 Dioxygenase 1 Market Analysis and Forecast by Application
   6.1. Market Trends
   6.2. Introduction
      6.2.1. Basis Point Share (BPS) Analysis by Application
      6.2.2. Y-o-Y Growth Projections by Application
   6.3. Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Application
      6.3.1. Aolpecia
      6.3.2. Cervical Cancer
      6.3.3. Gastric Cancer
      6.3.4. Glioma
      6.3.5. Others
   6.4. Absolute $ Opportunity Assessment by Application
   6.5. Market Attractiveness/Growth Potential Analysis by Application

7. Global Indoleamine 2,3 Dioxygenase 1 Market Analysis and Forecast by Sales Channel
   7.1. Market Trends
   7.2. Introduction
      7.2.1. Basis Point Share (BPS) Analysis by Sales Channel 
      7.2.2. Y-o-Y Growth Projections by Sales Channel
   7.3. Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Sales Channel 
      7.3.1. Manufacturer/Distributor/Service Provider
      7.3.2. Aftermarket
   7.4. Absolute $ Opportunity Assessment by Sales Channel
   7.5. Market Attractiveness/Growth Potential Analysis by Sales Channel

8. Global Indoleamine 2,3 Dioxygenase 1 Market Analysis and Forecast by Region
   8.1. Market Trends
   8.2. Introduction
      8.2.1. Basis Point Share (BPS) Analysis by Region
      8.2.2. Y-o-Y Growth Projections by Region
   8.3. Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Region
      8.3.1. North America
      8.3.2. Latin America
      8.3.3. Europe
      8.3.4. Asia Pacific
      8.3.5. Middle East and Africa (MEA)
   8.4. Absolute $ Opportunity Assessment by Region
   8.5. Market Attractiveness/Growth Potential Analysis by Region
   8.6. Global Indoleamine 2,3 Dioxygenase 1 Demand Share Forecast, 2019-2029

9. North America Indoleamine 2,3 Dioxygenase 1 Market Analysis and Forecast
   9.1. Introduction
      9.1.1. Basis Point Share (BPS) Analysis by Country
      9.1.2. Y-o-Y Growth Projections by Country
   9.2. North America Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Country
      9.2.1. U.S.
      9.2.2. Canada
   9.3. Absolute $ Opportunity Assessment by Country
   9.4. North America Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Application
      9.4.1. Aolpecia
      9.4.2. Cervical Cancer
      9.4.3. Gastric Cancer
      9.4.4. Glioma
      9.4.5. Others
   9.5. Basis Point Share (BPS) Analysis by Application
   9.6. Y-o-Y Growth Projections by Application
   9.7. North America Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Type
      9.7.1. BMS-986205
      9.7.2. Dcellvax
      9.7.3. Epacadostat
      9.7.4. F-001287
      9.7.5. Galanal
      9.7.6. Others
   9.8. Basis Point Share (BPS) Analysis by Type
   9.9. Y-o-Y Growth Projections by Type
   9.10. Market Attractiveness/Growth Potential Analysis
      9.10.1. By Country
      9.10.2. By Product Type
      9.10.3. By Application
      9.10.4. By Sales Channel
   9.11. North America Indoleamine 2,3 Dioxygenase 1 Demand Share Forecast, 2019-2029

10. Latin America Indoleamine 2,3 Dioxygenase 1 Market Analysis and Forecast
   10.1. Introduction
      10.1.1. Basis Point Share (BPS) Analysis by Country
      10.1.2. Y-o-Y Growth Projections by Country
      10.1.3. Latin America Average Pricing Analysis
   10.2. Latin America Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Country
      10.2.1. Brazil
      10.2.2. Mexico
      10.2.3. Rest of Latin America
   10.3. Absolute $ Opportunity Assessment by Country
   10.4. Latin America Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Application
      10.4.1. Aolpecia
      10.4.2. Cervical Cancer
      10.4.3. Gastric Cancer
      10.4.4. Glioma
      10.4.5. Others
   10.5. Basis Point Share (BPS) Analysis by Application
   10.6. Y-o-Y Growth Projections by Application
   10.7. Latin America Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Type
      10.7.1. BMS-986205
      10.7.2. Dcellvax
      10.7.3. Epacadostat
      10.7.4. F-001287
      10.7.5. Galanal
      10.7.6. Others
   10.8. Basis Point Share (BPS) Analysis by Type
   10.9. Y-o-Y Growth Projections by Type
   10.10. Market Attractiveness/Growth Potential Analysis
      10.10.1. By Country
      10.10.2. By Product Type
      10.10.3. By Application
      10.10.4. By Sales Channel
   10.11. Latin America Indoleamine 2,3 Dioxygenase 1 Demand Share Forecast, 2019-2029

11. Europe Indoleamine 2,3 Dioxygenase 1 Market Analysis and Forecast
   11.1. Introduction
      11.1.1. Basis Point Share (BPS) Analysis by Country
      11.1.2. Y-o-Y Growth Projections by Country
      11.1.3. Europe Average Pricing Analysis
   11.2. Europe Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Country
      11.2.1. Germany
      11.2.2. France
      11.2.3. Italy
      11.2.4. U.K.
      11.2.5. Spain
      11.2.6. Russia
      11.2.7. Rest of Europe
   11.3. Absolute $ Opportunity Assessment by Country
   11.4. Europe Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Application
      11.4.1. Aolpecia
      11.4.2. Cervical Cancer
      11.4.3. Gastric Cancer
      11.4.4. Glioma
      11.4.5. Others
   11.5. Basis Point Share (BPS) Analysis by Application
   11.6. Y-o-Y Growth Projections by Application
   11.7. Europe Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Type
      11.7.1. BMS-986205
      11.7.2. Dcellvax
      11.7.3. Epacadostat
      11.7.4. F-001287
      11.7.5. alanal
      11.7.6. Others
   11.8. Basis Point Share (BPS) Analysis by Type
   11.9. Y-o-Y Growth Projections by Type
   11.10. Market Attractiveness/Growth Potential Analysis
      11.10.1. By Country
      11.10.2. By Product Type
      11.10.3. By Application
      11.10.4. By Sales Channel
   11.11. Europe Indoleamine 2,3 Dioxygenase 1 Demand Share, 2019-2029

12. Asia Pacific Indoleamine 2,3 Dioxygenase 1 Market Analysis and Forecast
   12.1. Introduction
      12.1.1. Basis Point Share (BPS) Analysis by Country
      12.1.2. Y-o-Y Growth Projections by Country
      12.1.3. Asia Pacific Average Pricing Analysis
   12.2. Asia Pacific Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Country
      12.2.1. China
      12.2.2. Japan
      12.2.3. South Korea
      12.2.4. India
      12.2.5. Australia
      12.2.6. Rest of Asia Pacific (APAC)
   12.3. Absolute $ Opportunity Assessment by Country
   12.4. Asia Pacific Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Application
      12.4.1. Aolpecia
      12.4.2. Cervical Cancer
      12.4.3. Gastric Cancer
      12.4.4. Glioma
      12.4.5. Others
   12.5. Basis Point Share (BPS) Analysis by Application
   12.6. Y-o-Y Growth Projections by Application
   12.7. Asia Pacific Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Type
      12.7.1. BMS-986205
      12.7.2. Dcellvax
      12.7.3. Epacadostat
      12.7.4. F-001287
      12.7.5. Galanal
      12.7.6. Others
   12.8. Basis Point Share (BPS) Analysis by Type
   12.9. Y-o-Y Growth Projections by Type
   12.10. Market Attractiveness/Growth Potential Analysis
      12.10.1. By Country
      12.10.2. By Product Type
      12.10.3. By Application
      12.10.4. By Sales Channel
   12.11. Asia Pacific Indoleamine 2,3 Dioxygenase 1 Demand Share, 2019-2029

13. Middle East & Africa Indoleamine 2,3 Dioxygenase 1 Market Analysis and Forecast
   13.1. Introduction
      13.1.1. Basis Point Share (BPS) Analysis by Country
      13.1.2. Y-o-Y Growth Projections by Country
      13.1.3. Asia Pacific Average Pricing Analysis
   13.2. Middle East & Africa Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Country
      13.2.1. Saudi Arabia
      13.2.2. South Africa
      13.2.3. UAE
      13.2.4. Rest of Middle East & Africa (MEA)
   13.3. Absolute $ Opportunity Assessment by Country
   13.4. Middle East & Africa Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Application
      13.4.1. Aolpecia
      13.4.2. Cervical Cancer
      13.4.3. Gastric Cancer
      13.4.4. Glioma
      13.4.5. Others
   13.5. Basis Point Share (BPS) Analysis by Application
   13.6. Y-o-Y Growth Projections by Application
   13.7. Middle East & Africa Indoleamine 2,3 Dioxygenase 1 Market Size and Volume Forecast by Type
      13.7.1. BMS-986205
      13.7.2. Dcellvax
      13.7.3. Epacadostat
      13.7.4. F-001287
      13.7.5. Galanal
      13.7.6. Others
   13.8. Basis Point Share (BPS) Analysis by Type
   13.9. Y-o-Y Growth Projections by Type
   13.10. Market Attractiveness/Growth Potential Analysis
      13.10.1. By Country
      13.10.2. By Product Type
      13.10.3. By Application
      13.10.4. By Sales Channel
   13.11. Middle East & Africa Indoleamine 2,3 Dioxygenase 1 Demand Share, 2019-2029

14. Competition Landscape
   14.1. Global Indoleamine 2,3 Dioxygenase 1 Market: Market Share Analysis
   14.2. Indoleamine 2,3 Dioxygenase 1 Distributors and Customers
   14.3. Indoleamine 2,3 Dioxygenase 1 Market: Competitive Dashboard
   14.4. Company Profiles (Details – Overview, Financials, Developments, Strategy) 
      14.4.1. BirchBioMed Inc Overview Financials Developments Strategic Outlook
      14.4.2. Bristol-Myers Squibb Company Overview Financials Developments Strategic Outlook
      14.4.3. Ensemble Therapeutics Corp Overview Financials Developments Strategic Outlook
      14.4.4. F. Hoffmann-La Roche Ltd Overview Financials Developments Strategic Outlook
      14.4.5. Genentech Inc Overview Financials Developments Strategic Outlook
      14.4.6. Globavir Biosciences Inc Overview Financials Developments Strategic Outlook
      14.4.7. Incyte Corp Overview Financials Developments Strategic Outlook
      14.4.8. IO Biotech ApS Overview Financials Developments Strategic Outlook
      14.4.9. Kyowa Hakko Kirin Overview Financials Developments Strategic Outlook
      14.4.10. Netherlands Translational Research Center BV Overview Financials Developments Strategic Outlook
      14.4.11. NewLink Genetics Corp Overview Financials Developments Strategic Outlook
      14.4.12. Pfizer Inc Overview Financials Developments Strategic Outlook
      14.4.13. Redx Pharma Plc Overview Financials Developments Strategic Outlook
      14.4.14. Regen BioPharma Inc Overview Financials Developments Strategic Outlook
      14.4.15. COMPANY 15 Overview Financials Developments Strategic Outlook
      14.4.16. COMPANY 16 Overview Financials Developments Strategic Outlook
      14.4.17. COMPANY 17 Overview Financials Developments Strategic Outlook
      14.4.18. COMPANY 18 Overview Financials Developments Strategic Outlook
      14.4.19. COMPANY 19 Overview Financials Developments Strategic Outlook
      14.4.20. COMPANY 20 Overview Financials Developments Strategic Outlook

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